Injections of botulinum toxin may help prevent migraines in people who suffer frequent migraine attacks. Doctors evaluated the efficacy and safety of a single series of Botox injections, versus placebo shots, for preventing migraine.
Botox may be a useful treatment option for headache patients who aren't doing well on other migraine preventive agents. They reported Botox had beneficial, albeit limited, effects on measures of migraine frequency and was not effective in lowering headache pain severity.
Botox is made from a diluted form of botulinum toxin A. The Food and Drug Administration approved Botox in 1989, after testing in animals showed that the toxin did not travel to the brain. The approval was for treating uncontrollable blinking and misaligned (''lazy'') eyes.